Endocrine Abstracts

Background: Generally, abdominal adipose tissue correlates stronger to decreased insulin sensitivity than what BMI does. In adults, males have more visceral adipose tissue (VAT) and less subcutaneous adipose tissue (SAT) than females. Comparisons between measures of body composition from magnetic resonance imaging (MRI), dual x-ray absorptiometry (DXA) and anthropometry have been studied previously; however not in preschool children.Aim: This study compa...

Phthalates are man-made chemicals that are used in many different types of products. The main use is as plasticizers, but they can also be added to, for example, cosmetics, drug coatings, and perfumes. One of the most commonly used phthalates is di-butyl phthalate (DBP), which has been detected in both food and drinking water globally. Once ingested, DBP is rapidly metabolized to its main metabolite, mono-butyl phthalate (MBP), which is frequently detected in human plasma and ...

Introduction: In a fraction of morbidly obese subjects undergoing gastric bypass (GBP), episodes with late postprandial hypoglycemia (PPHG) develop 1–3 years after surgery. The pathogenesis of this phenomenon is not fully understood; meal-induced rapid and exaggerated increases of circulating incretins and insulin appear to be partially responsible. Current treatments include low-carbohydrate diets, inhibition of glucose intestinal uptake, reduction of insulin secretion w...

Chemical contaminants from human activity are omnipresent in the environment. A great number of common industrial compounds are detected in human blood and urine. Common chemicals such as bisphenols, phthalates and parabens that can interfere with endocrine signaling are classified as endocrine disruptive compounds (EDCs). The sex steroid hormonal signaling pathway is complex and sensitive to interference, as circulating concentrations of these hormones are low. Even miniscule...

Objective: Vitamin D and osteoporosis in Graves’ disease (GD) have previously been examined in cross-sectional studies with partly divergent results. Here, we prospectively studied vitamin D metabolism and bone health in patients with newly diagnosed GD.Methods: Thirty consecutive patients with de novo overt thyrotoxicosis diagnosed with GD were included. None of the patients at diagnosis were treated with vitamin D supplementation or anti ...

Background: The aim of the Swedish Pituitary Register – the Swedish Pituitary Study Group’s quality register – is to guarantee that all patients with pituitary tumours get equivalent diagnostic evaluation and treatment, as well as to evaluate given therapy. In this study, patients diagnosed with acromegaly from 1991 are described.Methods: Data from 557 patients (275 men/282 women), median age 51 years (range 4–87), with acromegaly wer...

Central treatment with ghrelin increases body weight and fat accumulation. Here we explore the pharmacological effect of a combined central (ICV) infusion of ghrelin (0.3 nmol/day) and a recently developed ghrelin receptor (GHS-R1A) antagonist (JMV2959, 100 nmol/day) on food intake and body composition. The effect of ghrelin infusion for 14 days to increase body weight (20.7±0.9% vs 34.3±3.1%, saline vs ghrelin, P<0.001) was blocked by co-infusion with JMV...